|Statement||By Fred. C. Blanck ...|
|LC Classifications||QD341.A8 B56|
|The Physical Object|
|Pagination||37,  p.|
|Number of Pages||37|
|LC Control Number||09024663|
The major uses of aniline are in the manufacture of polymers, rubber, agricultural chemicals, dyes and pigments, pharmaceuticals, and photographic chemicals. Most derivatives of aniline are prepared by hydrogenation of their nitroaromatic precursors. An important derivative of aniline is 4,4′‐methylenedianiline (4,4′‐MDA).Cited by: This article is cited by 6 publications. Priyanka Chaudhary, Surabhi Gupta, Nalluchamy Muniyappan, Shahulhameed Sabiah, Jeyakumar Kandasamy. Regioselective Nitration of N-Alkyl Anilines using tert-Butyl Nitrite under Mild by: 6. The flash point of aniline (70°C) is well above its normal storage temperature, but aniline should be stored and used in areas with minimum fire hazard. Aniline is slightly corrosive to some metals. (b) Nitration: Direct nitration of aniline yields tarry oxidation products in addition to the nitro derivatives. Moreover, in the strongly acidic medium, aniline is protonated to form the anilinium ion which is meta directing. That is why besides the ortho and para derivatives, significant amount of meta derivative is also formed.
The invention relates to a method for carrying out the highly regioselective aromatic nitration of 4-alkanoylaminoalkyl-benzoic acid alkyl esters at the 5-position in a mixture containing nitric acid. The invention also relates to the use of the products obtained using said method and to the production of benzimidazole derivatives which are, in particular, pharmaceutically active. Nevertheless it is clear that certain special mechanisms, dependent on nitrous acid, intervene in the nitration of phenol and aniline derivatives, and we have been attempting to throw some light. The flash point of aniline (70°C) is well above its normal storage temperature, but aniline should be stored and used in areas with minimum fire hazard. Aniline is slightly corrosive to some metals. It attacks copper, brass, and other copper alloys, and use of these metals should be avoided in equipment that is used to handle aniline. Direct nitration of aniline yields tarry oxidation products in addition to the nitro er, in strongly acidic medium, aniline is protonated to form anilinium ion which is meta directing. That is why, besides ortho (2%) and para (51%) derivatives, significant amount (47%) of meta derivatives .
Reacting 4-substituted aniline derivatives with chlorosulfonyl isocyanate gives the N-acylated products (R = Me, Et, Pr i, Ph; R 1 = H, Cl), which then cyclize to the 4-alkylated 2H-benzothia-2,4-diazine-3(4H)-one 1,1-dioxides in the presence of AlCl 3 (Scheme 13).This reaction constitutes the use of [3+3] fragments and is discussed further in that context in. Purchase Nitration of Hydrocarbons and Other Organic Compounds - 1st Edition. Print Book & E-Book. ISBN , In the nitration of aniline reaction, meta isomer is also observed along with para because the aniline molecule gets protonated in an acidic medium to become an Anilion ion. Though the NH 2 group is an o and p indicator, when the reaction takes place with acid, it produces meta-Nitroaniline. Sulphonation of Aniline (image will be uploaded soon). Aniline is an organic compound with the formula C 6 H 5 NH ting of a phenyl group attached to an amino group, aniline is the simplest aromatic is an industrially significant commodity chemical, as well as a versatile starting material for fine chemical synthesis.